Patents

Brevetto: Linda P., Gardossi L., Toniutti M. (2004) “Process for the enzymatic synthesis of ß-lactam antibiotics.” PCT/EP2004/000182; WO 2004062558 A3.  

Brevetto: Basso A., Caimi P., Ciccarelli L., Daminati M., Ebert C., Gardossi L., "Support products for solid-phase synthesis and process for their preparation" patent IT 2007MI0782 A1. 

Brevetto: Gardossi L., Sinigoi L., Spizzo D., Fattor D. “Method for covalent immobilization of enzymes on functionalized solid polymeric supports.” WO2012085206 (A1); EP2655611 (A1) 

 Brevetto: Cerea G., Gardossi L., Sinigoi L., Fattor D. “Process for the production of polyesters through synthesis catalyzed by enzyme.” EP2620462 (A1); WO2013110446 (A1)   

Articles

  • F. Zappaterra, M. Renzi, M. Piccardo, M. Spennato, F. Asaro, M. Di Serio, R. Vitiello, R. Turco, A. Todea, L. Gardossi, Understanding Marine Biodegradation of Bio-Based Oligoesters and Plasticizers, Polymers 2023, 15(6), 1536
  • A. Todea, S. Fortuna, C. Ebert, F. Asaro, S. Tomada, M. Cespugli, F. Hollan, L. Gardossi, Rational guidelines for the two‐step scalability of enzymatic polycondensation: experimental and computational optimization of the enzymatic synthesis of poly (glycerolazelate), ChemSusChem, 2022, 2, 22.
  • V. Ferrario, A. Todea, L. Wolansky, N. Piovesan, A. Guarneri, D. Ribitsch, G. M Guebitz, L. Gardossi, A. Pellis, Effect of Binding Modules Fused to Cutinase on the Enzymatic Synthesis of Polyesters, Catalyst, 2022, 12, 3, 303
  • A. Todea, C. Deganutti, M. Spennato, F. Asaro, G. Zingone, T. Milizia, L. Gardossi, Azelaic Acid: A Bio-Based Building Block for Biodegradable, Polymers, 2021, 1, 13, 23, 4091
  • Fortuna S., Cespugli M., Todea A., Pellis A., Gardossi L., Criteria for Engineering Cutinases: Bioinformatics Analysis of Catalophores, Catalysts 2021, 11 (7), 784. 
  •  Spennato M. , Todea A., Corici L, Asaro F, Cefarin N., Savonitto G., Deganutti C., Gardossi G., Turning biomass into functional composite materials: rice husk for fully renewable immobilized biocatalysts EFB Bioeconomy Journal, 2021, 1, 
  •  F Fava, L Gardossi, P Brigidi, P Morone, DAR Carosi, A Lenzi, The bioeconomy in Italy and the new national strategy for a more competitive and sustainable country, New Biotechnology, 2021, 61, 124-136 
  •  Coloma, J.; Lugtenburg, T.; Afendi, M.; Lazzarotto, M.; Bracco, P.; Hagedoorn, P.-L.; Gardossi, L.; Hanefeld, U. Immobilization of Arabidopsis thaliana Hydroxynitrile Lyase (AtHNL) on EziG Opal. Catalysts 2020, 10, 899. 
  •  de Sousa Fonseca T., Benedetti Vega K., Reinaldo da Silva M., da Conceição Ferreira de Oliveira M., Gomes de Lemosa T. L., Contente M. L., Molinari F., Cespugli M., Fortuna S., Gardossi L., de Mattos M. C. Lipase mediated enzymatic kinetic resolution of phenylethyl halohydrins acetates: A case of study and rationalization, Mol. Cat. 2020, 485, 110819. https://doi.org/10.1016/j.mcat.2020.110819 
  •  Bracco P., van Midden N., Arango E., Torrelo G., Ferrario V., Gardossi L., Hanefeld U., Bacillus subtilis lipase A – lipase or esterase?, Catalysts 2020, 10, 308; doi:10.3390/catal10030308 
  •  Comerford J. W., Byrne F. P., Weinberger S., Farmer T. J., Guebitz G. M., Gardossi L., Pellis A., Thermal Upgrade of Enzymatically Synthesized Aliphatic and Aromatic Oligoesters. Materials 2020, 13, 368; doi:10.3390/ma13020368. 
  • Pellis A., Gardossi L., “Integrating computational and experimental methods for efficient biocatalytic synthesis of polyesters” in “Enzymatic polymerization”, Bruns N. and Loos K. Eds., Methods Enzymol, 2019, 627, 23-55 2019, 2019, 627. https://doi.org/10.1016/bs.mie.2019.07.040
  • Guarneri A., Cutifani V., Cespugli M., Pellis A., Vassallo R., Asaro F.,  Ebert C., and Gardossi L., “Functionalization of enzymatically-synthesized rigid poly(itaconates) via post-polymerization aza-Michael addition of primary amines”. 2019, Adv. Synth. Cat., 361, 2559-2573. DOI: doi/10.1002/adsc.201900055   
  •  Patrick C. F. Buchholz, P.C.F., Ferrario V., Pohl M., Gardossi L., Pleiss J., Navigating within thiamine diphosphate-dependent decarboxylases: sequences, structures, functional positions, and binding sites.  Proteins, 2019, doi: 10.1002/prot.25706.   
  •  Cipolla L., Gardossi L., “ Il nobel 2018 premia l’evoluzione della Chimica attraverso le biotecnologie”. La chimica e l’industria, 2019, 1, 28-34. 
  • Cespugli M., Lotteria S., Navarini L., Lonzarich V., Del Terra L., Vita F., Zweyer M., Baldini G., Ferrario V., Ebert C., Gardossi L., “Rice Husk as an Inexpensive Renewable Immobilization Carrier for Biocatalysts Employed in the Food, Cosmetic and Polymer Sectors”, Catalysts 2018, 8, 471-493; https://doi.org/10.3390/catal8100471 
  •  Pellis A, Cantone S., Ebert C., Gardossi L., “Evolving biocatalysis to meet bioeconomy challenges and opportunities”, New Biotechnol., 2018, 40, 154-169. DOI:  http://dx.doi.org/10.1016/j.nbt.2017.07.005. 
  • Pellis  A., Ferrario V., Cespugli M., Corici L., Guarneri A., Zartl B., Herrero Acero E., Ebert C., Guebitz,  Ebert  C., Guebitz G.M.,  Gardossi L.. “Fully renewable polyesters via polycondensation  catalyzed by Thermobifida cellulosilytica cutinase 1: an integrated approach”. Green Chem., 2017, 19, 490-502. DOI: 10.1039/C6GC02142E
  • Pellis A., Silvestrini L., Scaini D., Coburn J.M, Gardossi L., Kaplan D.L., Acero E.H., Guebitz G.M. Enzyme-catalyzed functionalization of poly(L-lactic acid) for drug delivery applications Process Biochem., 2017, 59, 77–83. http://dx.doi.org/10.1016/j.procbio.2016.10.014. 
  •  Ferrario V., Pellis A., Cespugli M., Guebitz G.M., Gardossi L., “Nature Inspired Solutions for Polymers: Will Cutinase Enzymes Make Polyesters and Polyamides Greener?” Catalysts 2016, 6, 205; doi:10.3390/catal6120205 
  • Corici L., Ferrario V., Pellis A., Ebert C., Lotteria S., Cantone S., Voinovich D. and L. Gardossi, “Large scale applications of immobilized enzymes call for sustainable and inexpensive solutions: rice husk as renewable alternative to fossil-based organic resins.” RSC Adv., 2016, 6, 63256-63270.  
  • Pellis A., V. Ferrario, B. Zartl, M. Brandauer, C. Gamerith, E. Herrero Acero, C. Ebert, L.Gardossi, G. M. Guebitz “Enlarging the tools for efficient enzymatic polycondensation: structural and catalytic features of cutinase 1 from Thermobifida cellulosilytica.” Catal. Sci. Technol., 2016, 6, 3430-3442. 
  •   Pellis A., Acero E. H., Gardossi L., Ferrario V., Guebitz G.M. “Renewable building blocks for sustainable polyesters: new biotechnological routes for greener plastics”. Polym. Int., 2016, 65, 861-871. 
  •   Pellis A.,  Guarneri A., Brandauer M., Herrero Acero E., Peerlings H, Gardossi L., Guebitz G.M. “Exploring mild enzymatic sustainable routes for the synthesis of bio-degradable  aromatic-aliphatic oligoesters”. Biotechnol. J., 2016, 11, 642-647. 
  •   Ferrario V., Siragusa L., Ebert C., Cruciani G.,  Gardossi L., “Molecular descriptors for the structural analysis of enzyme active sites, in Understanding enzymes; Function, Design, Engineering and Analysis, Allan Svendsen ed., Pan Stanford Publishing Pte Ltd., 2016, pag.465-495. DOI: 10.4032/9789814669337 
  • Pellis A., Acero E. H., Ferrario V., Ribitsch D., Guebitz G. M., Gardossi L., “The closure of the cycle: enzymatic synthesis and functionalization of bio-based polyesters” Trends Biotechnol., 2016, 34, 316-328. DOI: 10.1016/j.tibtech.2015.12.009. 
  •   Ferrario V., Chernykh A., Fiorindo F., Kolomytseva M., Sinigoi L., Myasoedova N., Fattor D., Ebert C., Golovleva L., Gardossi L.,  “Investigating the Role of Conformational Effects on Laccase Stability and Hyperactivation under Stress Conditions”. 2015, Chembiochem,  6, 2365-72. doi: 10.1002/cbic.201500339. 
  •   Fernandi M., Baroni M., Bazzurri M., Benedetti P., Chiocchini D., Decastri D., Ebert C., Gardossi L., Randazzo G. M., Clementi S., “The CARSO (Computer Aided Response Surface Optimization) procedure in Optimization StudiesApplied”. Applied Mathematics, 2015, 6, 1947-1956. 
  •   Ferrario V., Ebert C., Nitti P., Pitacco G., Gardossi L., “Modelling and predicting enzyme enantioselectivity: the aid of computational methods for the rational use of lipase B from Candida antarctica” Current biotechnology, 2015, 4, 87-99. DOI: 10.2174/2211550104666150610205931 
  •   Corici L., Pellis A., Ferrario V., Ebert C., Cantone S., Gardossi L., "Understanding potentials and restrictions of solvent-free enzymatic polycondensation of itaconic acid: an experimental and computational analysis". Adv. Synth. Cat., 2015, 357, 1763-1774. 
  •   Pellis A., Corici L., L. Sinigoi, N. D’Amelio, D. Fattor, V. Ferrario,  C. Ebert, L. Gardossi, “Towards feasible and scalable solvent-free enzymatic polycondensations: integrating robust biocatalysts with thin film reactions”. Green Chem., 2015, 17, 1756-1766 
  •   Ferrario V., Siragusa L., Ebert C., Baroni M., Foscato M., Cruciani G., Gardossi L., “BioGPS Descriptors for Rational Engineering of Enzyme Promiscuity and Structure Based Bioinformatic Analysis”. PLoS ONE 2014, 9(10): e109354. doi:10.1371/journal.pone.0109354  
  • Ferrario V., Ebert C., Svendsen A., Besenmatter W., Gardossi L., “An integrated platform for automatic design and screening of virtual mutants based on 3D-QSAR analysis” J. Mol. Cat. B: Enzymatic, 2014, 101, 7–15. 
  • Ferrario V., Foscato M., Ebert C., Gardossi L., “Thermodynamic analysis of enzyme enantioselectivity: a statistical approach by means of new differential HybridMIF descriptors”. Biocatal. Biotransform. 2013, 31, 272-280 
  •   Cantone S., Ferrario V, Corici L., Ebert C., Fattor D, Spizzo P., Gardossi L., “Efficient immobilisation of industrial biocatalysts: criteria and constraints for the selection of organic polymeric carriers and immobilisation methods”. Chem. Soc. Rev., 2013, 42, 6262-6276. 
  •   Ferrario V., Veny H., De Angelis E., Navarini L., Ebert C., Gardossi L., “Lipases Immobilization for Effective Synthesis of Biodiesel Starting from Coffee Waste Oils”, Biomolecules 2013, 3, 514-534; doi:10.3390/biom3030514 
  •   Baj G., Carlino D., Gardossi L., Tongiorgi E., “Towards a unified biological hypothesis for the BDNF Val66Met-associated memory deficits in humans: a model of impaired dendritic mRNA trafficking”, Front. Neurosci.  2013, doi: 10.3389/fnins.2013.00188. 
  •   Ebert C., Felluga F., Forzato C., Foscato M., Gardossi L., Nitti P., Pitacco G., Boga C., Caruana P., Micheletti G., Calonghi N., Masotti L., “Enzymatic kinetic resolution of hydroxystearic acids: A combined experimental and molecular modelling investigation”, J. Mol. Cat. B: Enzymatic, 2012, 83. 38– 45 
  •   Braiuca P., Khaliullin I., Svedas V., Knapic L., Fermeglia M.,  Halling P.J.,  Gardossi L. “BESSICC, a COSMO-RS Based Tool for In Silico Solvent Screening of Biocatalyzed Reactions”, Biotech. Bioeng., 2012, 109, 1864-1868.. DOI: 10.1002/bit.24439 
  •   Cantone S., Spizzo P., Fattor D., Ferrario V., Ebert C., Gardossi L., Lipases for bio-based chemistry. Efficient immobilised biocatalysts for competitive biocatalysed processes” Monographic supplement series: Catalysis applications - chimica oggi/Chemistry Today, 2012, 30,  22-26. 
  •   Ferrario V., Braiuca P., Tessaro P., Knapic L., Gruber C., Pleiss J., Ebert C., Eichhorn E., Gardossi L. “Elucidating the structural and conformational factors responsible for the activity and substrate specificity of alkanesulfonate monooxygenase”, J. Biomol. Struct. Dyn.”, 2012, 30, 74-88. 
  •   Ferrario V., Ebert C., Knapic L., Fattor D., Basso A., Spizzo P., Gardossi L.. “Conformational changes of lipases in aqueous media: a comparative computational study and experimental implications”, Adv. Synth. Catal. 2011, 353, 2466 – 2480 
  •   Al-Zuhair S., Ramachandran K. B., Farid M., Vadlani P., Ramakrishnan S.  and Gardossi L., “Enzymes in Biofuels Production,” Enzyme Research, vol. 2011, Article ID 658263, 2 pages, 2011. doi:10.4061/2011/658263  
  • Pace V., Cabrera C. A., Ferrario V., Sinisterra V. J., Ebert C., Gardossi L., Braiuca P.,  Alcántara R. A., „Structural bases for understanding the stereoselectivity in ketone reductions with ADH from Thermus thermophilus: A quantitative model”, J. Mol. Cat. B., 2011, 70, 23-31.
  • Gardossi L., Poulsen P.B., Ballesteros A., Hult K., Vytas K. Švedas V.K., Vasić-Rački D., Carrea G., Magnusson A, Schmid A., Wohlgemuth R., J. Halling P.J., “Guidelines for reporting of biocatalytic reactions”, Trends Biotechnol., 2010, 28, 171-180. 
  •   Gardossi L., Halling P.J., “Guidelines for reporting of biocatalytic reactions”, Proceedings of the 4th International Symposium on Experimental Standard Conditions Of Enzyme Characterizations, Hicks M.G., Kettner C. Eds., Logos Verlag Berlin, 2010, 187-204. 
  •   Ricca E., Calabrò V., Curcio S., Iorio G., Gardossi L., Basso A., “Fructose production by inulinase covalently immobilized on Sepabeads in batch and fluidized bed bioreactor”, Int. J. Mol.Sci, 2010, 11, 1180-1189. 
  •   Basso A., Spizzo P., Ferrario V., Knapic L., Savko N., Braiuca P., Ebert C., Ricca E., Calabrò V., Gardossi L., “Endo and exoinulinases: enzyme-substrate interaction and rational immobilisation“, Biotechnol. Progr., 2010, 26, 397-405.
  • Gardossi, L., Molinari, F., “ Biocatalytic processes”, in “Catalysis” Ed. Gabriele Centi, Encyclopedy of Life Support Systems-EOLSS, UNESCO (United Nations Educational, Scientific and Cultural Organization). http://www.eolss.net/outlinecomponents/Catalysis.aspx 
  • Braiuca P., Knapic L., Ferrario V., Ebert C., Gardossi L., “A Three-Dimensional Quanititative Structure-Activity Relationship (3D-QSAR) Model for Predicting the Enantioselectivity of Candida antarctica Lipase B”, Adv. Synth. Catal. 2009, 351, 1293 – 1302. 
  •   Basso A., Sinigoi L., Gardossi L., Flitsch S., “Effect of Microwave Radiation on Enzymatic and Chemical Peptide Bond Synthesis on Solid Phase”, International Journal of Peptides, Volume 2009, Article ID 362482, 4 pages doi:10.1155/2009/362482. 
  •   Chiaruttini C., Vicario A., Lib Z., Baja G., Braiuca P., Wu Y., Lee F. S., Gardossi L., Baraban J. M., Tongiorgi E., “Dendritic trafficking of BDNF mRNA is mediated by translin and blocked by the G196A (Val66Met) mutation”,  Proc. Natl. Acad. Sci. USA 2009, 106, 16481-16486.
  • Hanefeld U., Gardossi L., Magner E., “Understanding Enzyme Immobilisation”, Chem. Soc. Rev., 2009, 38, 453-468.
  • Sinigoi L.,  Bravin P., Ebert C.,  D’Amelio N., Vaccari L.,| Ciccarelli L., Cantone S., Basso A., Gardossi L., “Synbeads Porous-Rigid Methacrylic Support: Application to Solid Phase Peptide Synthesis and Characterization of the Polymeric Matrix by FTIR Microspectroscopy and High Resolution Magic Angle Spinning NMR”, J. Comb. Chem. 2009, 11, 835–845. 
  •   Molinari F., Romano D., Gandolfi R., Gardossi L., Hanefeld U., Converti A., Spizzo P., “Direct esterification with dry mycelium of moulds: a (stereo)selective, mild and efficient method to obtain structurally different esters”, Modern Biocatalysis, pag. 79-91, T. Anthonsen, W. Fessner Eds., 2008 Wiley-VCH, Weinheim, Germany. 
  • Basso A., Gardossi L., Halling P., Cantone S., Ebert C. “Biocatalysis with undissolved solid substrates and products”, pag. 279-301 in “Organic synthesis with enzymes in non-aqueous media”, pag. 279-301, Carrea G. and Riva S. Eds., 2008 Wiley-VCH Verlag GmbH &Co. KGaA, Weinheim, Germany. 
  •   Gardossi L., Ebert C., Ferrario V., Braiuca P., Basso A., Vaccari L., “ L’ immobilizzazione di enzimi: nuove strategie sperimentali e computazionali per l’ottimizzazione di biocatalizzatori industriali”, La chimica e l’industria, 2008, 1, 106-112. 
  •   Spizzo P., Basso A., Ebert C., Gardossi L., Ferrario V., Romano D., Molinari F., “Resolution of (R,S)-flurbiprofen catalysed by dry mycelia in organic solvent”, Tetrahedron, 2007, 63, 11005-11010.
  •   Basso A., ., Braiuca P., Cantone S., Ebert C., Linda P., Spizzo P., Caimi P., Hanefeld U., Degrassi G. and Gardossi L., “In silico analysis of enzyme surface and glycosylation effect as a tool for efficient covalent immobilization of CalB and PGA on Sepabeads®”, Adv. Synth. Catal, 2007, 349, 877-886. 
  •   Braiuca P., Buthe A.,  Ebert C., Linda P., Gardossi L., “Prediction of Enzyme Thermostability by Volsurf Computational Method,” Biotechnol. J., 2006, 24, 419-425. 
  •   Braiuca, P., Ebert, C., Basso, A., Linda, P., Gardossi L., “Computational methods to rationalize experimental strategies in biocatalysis” Trends Biotechnol., 2006, 24, 419-425. 
  •   Fermeglia M., Braiuca P. Gardossi L., Pricl S., Halling P., “In silico prediction of medium effects on esterification equilibrium using the COSMO-RS method” Biotechnol.  Progr., 2006, 22, 1146-1152. 
  •   Basso, A., Braiuca, P., Ebert, C., Gardossi, L., Linda, P., “Properties and applications of supports for enzyme mediated transformations in solid phase synthesis” J. Chem. Technol. Biot., 2006, 81, 1626-1640. 
  •   Romano D., Ferrario V., Molinari F., Gardossi L., Sanchez Montero J.M. Torre, P., Converti A., "Kinetic resolution of (R, S)-1,2-O-isopropylideneglycerol by esterification with dry mycelia of moulds" J. Mol. Cat. B., 2006, 41, 71-74.
  • Basso A, Spizzo P., Toniutti M., Ebert C., Linda P., Gardossi L., “Kinetically controlled synthesis of ampicillin and cephalexin in highly condensed systems in the absence of a liquid aqueous phase” J. Mol. Catal. B: Enzymatic, 2006, 39, 105-111. 
  •   Carboni C. Kierkels H.G.T , Gardossi L., Tamiola L., Janssen D. B. and Quaedflieg P. J.L.M “Preparation of D-amino acids by enzymatic kinetic resolution using a mutant of penicillin-G acylase from E. coli” Tetrahedron-Asymmetr., 2006, 17, 245-251. 
  •   Braiuca P., Boscarol L., Ebert C., Gardossi L., Linda P.,  “3-D QSAR applied to the quantitative prediction of penicillin G amidase selectivity”, Adv. Synth. Catal., 2006, 348, 773-780. 
  •   Senerovic L., Stankovic N., Spizzo P., Basso A., Gardossi L., Vasiljevic B., Ljubijankic L., Tisminetzki S., Degrassi G., “High-level production and covalent immobilization of Providencia rettgeri penicillin G acylase (PAC) from recombinant Pichia pastoris for the development of a novel and stable biocatalyst of industrial applicability”, Biotech. Bioeng., 2006, 93, 344-354.
  • Basso A., Ebert C., Gardossi L., Linda P., Phuong T. T., Zhub M and Wessjohann L., “Penicillin G amidase catalysed hydrolysis of phenylacetic hydrazides: a new route to the solid phase chemoenzymatic synthesis and design of enzyme cleavable linkers”, Adv. Synth. Catal., 2005, 347, 963-966. 
  •   Basso A., Maltman B., Flitsch S. L., Margetts G., Brazendale I., Ebert C., Linda P., Verdelli S.and Gardossi L., “Optimized polymer-enzyme electrostatic interactions significantly improve penicillin G amidase efficiency in charged PEGA polymers”, Tetrahedron, 2005, 61, 971-976. 
  •   Carboni C.,. Quaedflieg P. J.L.M, Broxterman Q. B., Linda  P. and Gardossi L. “Quantitative enzymatic protection of D-amino acid methyl esters by exploiting "relaxed" enantioselectivity of Penicillin-G amidase in organic solvent”, Tetrahedron Lett., 2004, 45,  9649-9652. 
  •   Fermeglia M.; Pricl S.; Gardossi L.; Halling P. “Prediction of activities in enzyme catalysed reactions from ab-initio calculations”, in Proceedings GRICU Conference, 2004, 1189-1191.    
  •   Braiuca P., Cruciani G., Ebert C., Gardossi L., Linda P., “An innovative application of “flexible” GRID/PCA computational method: study of differences in selectivity between PGAs from E. coli and from a P. rettgeri mutant”, Biotechnol.Prog. 2004, 20, 1025-1031.  
  • Basso A., De Martin L., Ebert C., Gardossi L., Linda P., Verdelli S., Tam A., “Non-swelling macroporous Synbeads for improved efficiency of biotransformations on solid phase”, Chem. Eur. J., 2004, 10, 1007-1013. 
  •   Basso A., Ulijn, R. V., Flitsch S. L., Margett G., Ebert C., De Martin L., Linda P., Verdelli S., Gardossi L., “Introduction of permanently charged groups into PEGA resins leads to improved biotransformations on solid support”, Tetrahedron, 2004, 60, 689-594. 
  •   Strübing D., Neumann H., von Wangelin A. J., Gördes D., Beller M., Braiuca P., Ebert C., Gardossi L., Kragl U., “Enzymatic resolution of 4-N-phenylacetylamino-derivatives obtained from multicomponent reactions using PenG amidase and in silico studies ”, Tetrahedron, 2004, 60, 683-691. 
  •   Basso A., De Martin L., Ebert C., Gardossi L., Linda P., Sibilla F., “Organically modified xerogels as novel tailor-made supports for covalent immobilisation of enzymes (penicillin G acylase)”, Tetrahedron Lett., 2003,  44, 5889 – 5891.
  • Basso A., De Martin L., Ebert C., Gardossi L., Linda P., Ulijn R. V., Flitsch S. L., “Organically modified xerogels as supports for solid phase chemistry”, Tetrahedron Lett., 2003,  44, 6083-6085. 
  •   Basso A., De Martin L., Gardossi L., Margetts G., Brazendale I.,. Bosma A. Y., Ulijn R. V., Flitsch S. L., “Improved biotransformations on charged PEGA supports”, Chem. Commun., 2003, 1296.
  • Braiuca P., Ebert C., Fischer L., Gardossi L., Linda P., “Homology model of Penicillin acylase from Alcaligenes faecalis and in silico evaluation of its selectivity”, ChemBioChem., 2003, 4, 615-622. 
  •   Ulijn R. V., De Martin L., Gardossi L., Halling P.J. “Biocatalysis in reaction mixtures with undissolved solid substrates and products”, Current Org. Chem, 2003, 7, 1333-1346. DOI: 10.2174/1385272033486422 
  •   Ulijn R. V., De Martin L., Halling P. J., Janssen A.E.M., Gardossi L., Moore B. D., “Solvent selection for solid-to-solid synthesis”, Biotech. Bioeng., 2002, 80, 509-515.
  • Basso A., Braiuca P., Clementi S, Ebert C., Gardossi L., Linda P., “Computational analysis of the aminic subsite of PGA explains the influence of amine structure on enantioselectivity”,  J. Mol. Catal. B., 2002, 19-20, 423-430. 
  •   Biffi S., De Martin L., Ebert C., Gardossi L., Linda P., “Glutaryl 7-ACA acylase catalyses the synthesis of amide bond in heterogeneous substrate mixtures”,  J. Mol. Catal. B., 2002, 19-20, 423-430. 
  •   Basso A., Braiuca P., Ebert C., Gardossi L., Linda P., Benedetti F., “GRID/tetrahedral intermediate computational approach to the study of selectivity of penicillin G acylase in amide bond synthesis”, Biochim. Biophys. Acta , 2002, 1601, 85-92. 
  •   Basso A., Ducret A., Gardossi L., Lortie R., “Synthesis of octyl glucopyranoside by almond beta-glucosidase adsorbed onto Celite R-640”, Tetrahedron Lett., 2002, 43, 2005-2008. 
  •   Basso A., De Martin L., Ebert C., Gardossi, L., Linda P., “Selectivity of penicillin G acylase towards phenylacetic acid derivatives in amide bond synthesis in toluene”, J. Mol. Catal. B, 2001, 16, 73-80. 
  •   Basso A., Biffi S., De Martin L., Ebert C., Gardossi L., Linda P., “Quantitative acylation of amino compounds catalysed by penicillin G acylase in organic solvent at controlled aw.”, Croat. Chem. Acta, 2001, 74, 757-762. 
  •   Basso A., De Martin L., Ebert C., Gardossi L., Linda P., Zlatev, V., “Activity of covalently immobilised PGA in water miscible solvents at controlled aw.”, J. Mol. Catal. B: Enzymatic, 2001, 11, 851-855. 
  •   Gardossi L., “Immobilisation of Enzymes and Control of Water Activity in Low-Water Media: Properties and Applications of Celite R-640 (Celite Rods)”, in "Methods in Biotechnology: Enzyme in non-aqueous solvents: Methods and protocols", E.N. Vulfson, P.J.  Halling and H. Holland ed., Humana Press, Inc., Totowa, N.J., 2001, 151-172. 
  •   De Martin L., Ebert C., Gardossi L., Linda P., “High isolated yields in thermolysin-catalysed synthesis of Z-aspartyl-L-phenylalanine methyl ester in toluene at controlled water activity”, Tetrahedron Lett., 2001, 42, 3395-3397.  
  • Benedetti F., Berti F., Colombatti A., Flego M. Gardossi L., Linda P., Peressini S., ”Antibody Catalyzed Modification of Amino Acids. Efficient Hydrolysis of Tyrosine Benzoate”, Chem. Commun., 2001, 715-716. 
  •   Basso A., De Martin L., Ebert C., Gardossi L., Tomat A., Casarci M., Li Rosi O., “A novel support for enzyme adsorption: properties and application of aerogels in low water media”, Tetrahedron Lett., 2000, 41, 8627-8630.
  • Basso A., Braiuca, P., De Martin L., Ebert C., Gardossi L., Linda P., “D-Phenylglycine and D-4-Hydroxyphenylglycine Methyl Esters via Penicillin G Acylase Catalysed Resolution in Organic Solvents”, Tetrahedron-Asymmetr., 2000, 11, 1789-1796. 
  •   Basso A., De Martin L., Ebert C., Gardossi L., Linda P., “High isolated yields in thermodynamically controlled peptide synthesis in toluene catalysed by thermolysin adsorbed on Celite R-640”, Chem. Commun., 2000, 467-468. 
  •   Basso A., De Martin L., Ebert C., Gardossi L., Linda P., "Controlling the Hydration of Covalently Immobilised Penicillin G Amidase in Low-Water Medium: Properties and Use of Celite R-640", J. Mol. Catal. B, 2000, 8, 245-253.
  • De Martin L., Ebert C., Garau G., Gardossi L.; Linda P., “Penicillin G amidase in Low-Water Media: Immobilisation and Control of Water Activity by Means of Celite Rods”, J. Mol. Catal. B, 1999, 6, 437-445. 
  •   Gardossi L., Khan R., Konowicz P. A., Gropen L., Paulsen B.S., “Enzymatic Regioselective Deprotection of Peractilated Mono- and Disaccharides“, J. Mol. Catal. B, 1999, 6, 89-94. 
  •   Schergna S., Da Ros T., Linda P., Ebert C., Gardossi L., Prato M., “Enzymatic Modification of Fullerene Derivatives”, Tetrahedron Lett., 1998, 39, 7791-7794. 
  •   Ebert C., Gardossi L., Linda P., “Activity of Immobilised Penicillin Amidase in Toluene at Controlled Water Activity“, J. Mol. Catal. B, 1998, 5, 241-244. 
  •   Ebert C., Gardossi L., Linda P., "Control of Enzyme Hydration in Penicillin Amidase Catalysed Synthesis of Amide Bond", Tetrahedron Lett., 1996, 37, 9377-9380. 
  •   Ebert C., Gardossi L., Linda P., Vesnaver R., Bosco M., "Influence of Organic Solvents on Enzyme Chemoselectivity and Their Role in Enzyme-Substrate Interaction", Tetrahedron, 1996, 13, 4867-4876. 
  •   Khan R., Konowicz P. A., Gardossi L., Matulovà M., De Gennaro S., "Regioselective Deacetylation of Peracetylated Mono- and Disaccharides with Hydrazine Hydrate", Austr. J. Chem., 1996, 49, 293-298. 
  •   Ebert C., Gardossi L., Linda P., Tambwe K'A.-M., "Chemoselectivity and Enhanced Activity of Poly(ethylene glycol)-modified Lipases Acylating Hydrophilic Aminoacid Derivatives in Organic Solvents", Biotechnol. Tech., 1994, 8, 811-816. 
  •   Ebert C., Gardossi L., Gianferrara T., Linda P., Morandini C., "A Multivariate Re-examination of Experimental Condition Effects on Acyloin-Type Condensation Mediated by Saccharomyces Cerevisiae", Biocatalysis, 1994, 10, 15-23. 
  • Khan R., Konowicz P.A., Gardossi L., Matulovà M., Paoletti S., "Chemical Regioselective Hydrolysis of Peracetylated Reducing Disaccharides, Specifically at the Anomeric Centre: Intermediates of the Synthesis of Oligosaccharides", Tetrahedron Lett., 1994, 35, 4247-4250. 
  •   Ebert C., Ferluga G., Gardossi L., Gianferrara T., Linda P., “Improved Lipase-Mediated Resolution of Mandelic Acid Esters by Multivariate Investigation of Experimental Factors”, Tetrahedron-Asymm., 1992, 3, 903-912. 
  •   Berti F., Ebert C., Gardossi L., “One-Step Stereospecific Synthesis of a,ß-Dehydroaminoacid and Dehydropeptides”, Tetrahedron Lett., 1992, 33, 8145-8148. 
  •   Boccú E., Ebert C., Gardossi L. Gianferrara T., Linda P., Zacchigna M., “Enzymatic Synthesis of Ampicillin: a Chemometric Optimization”, Il Farmaco, 1991, 46, 565-577. Gardossi L., Bianchi D., Klibanov A.M., “Selective Acylation of Peptides Catalyzed by Lipases in Organic Solvents”, J. Am. Chem. Soc., 1991, 113, 6328-6329. 
  •   Boccú E., Gianferrara T., Gardossi L., Veronese F.M., “ E. coli Penicillin Acylase: Purification and Covalent Binding to Nylon”, Il Farmaco, 1990, 45, 203-214. 
  •   Boccú E., Ebert C., Gardossi L., Gianferrara T., Linda P., “Chemometric Optimization of an Asymmetric Reduction Catalyzed by Baker's Yeast”, Biotech. Bioeng., 1990, 35, 928-934.