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PhD courses Supervisor: Prof. Lucio Randaccio
Description of activity
Crystallography of proteins and miniaturised proteins The PhD program in biocrystallography is designed for individuals with both strong physico-chemical skills and a background or interest in the bio-molecular sciences, and aims to train researchers that can apply these approaches and related methodologies to both basic and industry research.
Aims
- To provide trained individuals with experience in crystallisation methods, X-ray protein structural determination, molecular modelling and related methods for both academic and industrial research centers.
- To facilitate the spread of biocrystallography, molecular modelling and related methods by organising seminars and meetings for students.
- To promote the synergistic interaction of this subject group with others, both within the RSC and outside.
Program
1. X-ray diffraction theory
2. Basic Structural Principles
- Organisation in Protein Structure: Simple Motifs
- Protein Structure
- Structure/properties relationships
- Role of the metal in metalloproteins
3. Crystallisation techniques for biological materials.
4. X-Ray data collection with conventional and synchrotron sources
- Data treatment and methods for solving and refining crystal structure of proteins.
5. Databases in Molecular Sciences
6. Molecular Modelling
7. Structure determination of metalloproteins.
PhD students in Chemical Sciences:
Gianpiero Garau, Mara Campagnolo, Luigi Di Costanzo
Supervisor: Prof. Maurizio Prato
Description of activity
The PhD program in bioinformatics and molecular modelling is designed for individuals with both strong mathematical/computational skills and a background or interest in the biological or health sciences, and aims to train researchers that can apply these approaches and related methodologies to both basic research or industrial R&D.
Aims
· To promote awareness in the potentials and limitations of bioinformatics in the identification of novel drug targets, and of molecular modelling in the design of lead compounds for these drugs. · To provide trained individuals that will increase the cost-effectiveness of molecular modelling and related methods in experimental research programs across all industrial sectors
· To facilitate the spread of bioinformatics, molecular modelling and related methods by organising seminars and meetings for research managers and technical personel
· To promote the synergistic interaction of this subject group with others, both within the RSC and outside,
Program
1. Molecular Interactions & Dynamics
- Basic Structural Principles
- Organisation in Protein Structure: Simple Motifs
- Protein Structure
- Nucleic Acid Structure
- Homology Model
2. Biocomputing
- Protein and DNA sequence analysis
- Structure prediction
- Profiles HMMs
- Pattern Detection
- Genome Analysis
3. Statistical Analysis
4. Databases in Molecular Sciences
- Introduction to Databases
- Sequences Databases
- Molecular Databases
- Creating databases
5. Molecular Modelling
- Molecular modeling packages
- Building or modifying biomolecules
- Molecular mechanics techniques
- Molecular dynamics techniques
- Molecular docking
6. Configurational Search Techniques
7. Computer-assisted Combinatorial Chemistry
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